The study of parallel and distributed applications and platforms, whether in the cluster, grid, peer-to-peer, volunteer, or cloud computing domain, often mandates empirical evaluation of proposed algorithm and system solutions via simulation. Unlike direct experimentation via an application deployment on a real-world testbed, simulation enables fully repeatable and configurable experiments that can often be conducted quickly for arbitrary hypothetical scenarios. In spite of these promises, current simulation practice is often not conducive to obtaining scientifically sound results. State-of-the-art simulators are often not validated and their accuracy is unknown. Furthermore, due to the lack of accepted simulation frameworks and of transparent simulation methodologies, published simulation results are rarely reproducible. We highlight recent advances made in the context of the SimGrid simulation framework in a view to addressing this predicament across the aforementioned domains. These advances, which pertain both to science and engineering, together lead to unprecedented combinations of simulation accuracy and scalability, allowing the user to trade off one for the other. They also enhance simulation usability and reusability so as to promote an Open Science approach for simulation-based research in the field.